(Paper) IT – CLUB,KANNUR MEDICAL COLLEGE FIRST YEAR MBBS SECOND INTERNAL EXAMINATION - 2006 AMINO ACID METABOLISM
IT – CLUB,KANNUR MEDICAL COLLEGE
FIRST YEAR MBBS SECOND INTERNAL EXAMINATION - 2006
AMINO ACID METABOLISM
1)Describe the general reactions of aminoacid metabolism.
2) Describe Urea cycle/Krebs-Henseleit cycle/Biosynthesis of urea/ Detoxification of ammonia.
3)Describe the metabolism of glycine. Why glycine is non-essential?
4) Describe the metabolism of pheny alnine and tyrosine. / Trace the pathway for the metabolism of phenyl alanine.
5) Give an account of metabolism of tryptophan.
6) Give an account of metabolism of glutamic acid, aspartic acid, glutamine & asparagines. Describe the intermediary metabolism of Acidic amino acids.
7) Give an acoount of metabolism of methionine & cysteine / sulphur containing amino acids.
8) Describe the metabolic role and compounds synthesizing from serine.
9) What are the sources of ammonia? Describe the formation and fate of ammonia in the body. Give an account of metabolic disorders associated with this pathway.
10) How is niacin synthesized from tryptophan? What is the significance of Tryptophan load test?
11) Name the optically inactive amino acid and outline the biologically important compounds from it.
12) Describe the various inborn errors of amino acid metabolism, underlying metabolic defects, with a note on the detection of these errors.
13) Describe One carbon metabolism.
SHORT QUESTIONS
1) What is creatinine? Write a note on its excretion in urine.
2) What is meant by glucogenic and ketogenic amino acids?
3)Metabolic disorders of Urea cycle.
4) Inborn errors of phenyl alanine and tyrosine metabolism.
5) Inborn errors of tryptophan metabolism
6) Metabolic defects in glycine metabolism.
7) Note on Mono Amine Oxidase [MAO] inhibitor.
8) FIGLU Excretion test.
9) Metabolic error of Histidine metabolism.
10) Metabolic disorder of branched chain aminoacids/ Maple Syrup Urine Disease [MSUD]
11) Metabolic disorders of methionine metabolism.
12) Polyamines
13) GABA
14) Formation of serine from 3 – Phosphoglycerate.
15) Albinism
16) Alkaptonuria.
17) Phenylketonuria / Hyperphenylalaninemia Type 1
18) Nitrogen balance. How is dietary inadequacy can lead to such states?
19) Structure, synthesis and functions of Glutathione.
20) Role of SAM in amino acid metabolism.
21) What is creatine? How it is synthesized?
22) Give the reaction catalysed by Glutamate dehydrogenase.
23) Write the significance of Glutamate dehydrogenase reaction.
24) Write synthesis, functions and degradation of Serotonin.
25) How is S – adenosyl methionine formed? Give its 2 uses.
26) Give 3 functions of PLP in aminoacid metabolism.
27) How is indicant formed?
28) Transdeamination reaction ?
29) Transamination reaction with 2 examples.
30) Write the biological and clinical significance of Transamination reaction.
31) Active methionine.
32) How is PAPS [Active Sulphate] formed? Give its functions.
33) What is the significance of indicanuria?
34) What is the normal range of blood urea? Define uremia.
35) Transmethylation reaction and give its significance.
36) Synthesis and functions of thyroid hormones.
37) Urinary VMA
38) Explain negative and positive nitrogen balance
39) Formiminoglutamic acid.
40) Synthesis and metabolism of Epinephrine
41) Homocystinuria
42) Hyperammonemias.
43) Write pathway of catecholamine biosynthesis.
44) How is carbamoyl phosphate formed? Explain its metabolic role.
45) Why patients with Hartnup’s disease manifest pellagra like symptoms?
46) Alpha methyl dopa is used as an antihypertensive drug. Give reason.
47) Digestion of proteins.
48) Write the biochemical defect in :-
a) phenyl ketonuria
b) alkaptonuria
c) Hartnup’s disease.
d) Homocystenuria.
49) Explain the decarboxylation of aminoacids and its biological significance.
50) One carbon units.
51) How is N-acetyl glutamate synthesized? Explain the role of NAG in the regulation of Urea cycle.
52) Write the formation and function of Taurine.
53) How is melatonin synthesized? Write its functions.
54) Name the major excretory products of tryptophan.
55) Aminoacidurias.
56) Hypertyrosinemias.
57) Write the role of Vit B6 in aminoacid metabolism.
58) Thyroxine
Source : http://www.kmcmedicos.com
- guru's blog
- Login to post comments