(Paper) IT – CLUB, KANNUR MEDICAL COLLEGE FIRST YEAR MBBS SECOND INTERNAL EXAMINATION - 2006 BIOCHEMISTRY
IT – CLUB, KANNUR MEDICAL COLLEGE
FIRST YEAR MBBS SECOND INTERNAL EXAMINATION - 2006
BIOCHEMISTRY
Maximum marks : 50 Time:2 hrs
Instructions :Answer all questions
Draw neat diagrams wherever necessary.
SECTION – A
MCQ (½ x 10 = 5 MARKS)
1)The number of carbon atoms present in stearic acid is :
a) 14 b) 20
c) 18 d) 16
2) ------ is a competitive inhibitor of dihydrofolate reductase
a) allopurinol
b) amphethamine
c) amethopterin
d) sulphanilamide
3) under anaerobic conditions, the number of ATP synthesized in Glycolysis is
a) 1 b) 2
c) 4 d) 8
4)of the two amino groups present in urea, one is derived from ammonia while other comes from------
a) glutamate b) asparagine
c) glutamine d) aspartate
5) erythrocyte haemolysis occurs in the impairment of------
a) pentose phosphate pathway b) fructose metabolism
c) uronic acid pathway d) galactose metabolism
6)The characteristic feature of brown adipose tissue is
a) not involved in the thermogenesis
b) presence of numerous mitochondria
c) concerned with energy storage
d) made of spherical cell
7)The formation of B6 coenzyme is inhibited by the drug:
a) isonicotinic acid hydrazide (INH)
b) sulphanilamide
c) aminopterin
d) trimethoprim
8)VMA is the major end product of metabolism of----
a) catecholamine b) thyroxine
c) PTH d) calcitonin
9)The major structural protein is
a) collagen b) albumin
c) fibrinogen d) globulin
10) Primary ketone body is
a) acetone b)acetoacetic acid
c) beta hydroxyl butyric acid d) propionic acid
WRITE ESSAY: (1 X 10 = 10 MARKS)
A) Describe the De novo synthesis of Fatty acid. Add a note on
the role of citrate in this process
B)
Give one example for each.
a) Give a note on enzyme inhibition with its classification.
b) explain urea cycle
SECTION – B
ANSWER BRIEFLY ON (5 X 3 = 15 MARKS)
1)Significance of citric acid cycle
2)Explain troponin as a marker for MI
3)Discuss any 6 fates of glycine.
4)Draw the schematic representation of mitochondrial ETC and give any 2 inhibitors of ETC
5)Uronic acid pathway
GIVE BRIEF AND PRECISE ANSWERS (5 X 2 = 10 MARKS)
1)give any 2 gycogen storage disease, enzyme deficiency and clinical findings.
2)Give normal values of :
a) Hb in male and female
b)Serum cholesterol
c)Blood urea
d)FBS value
3) what is the role of carnitine in beta – oxidation?
4) How SAM is synthesized and give any one reaction where it is involved.
5)Write the biochemical defect in
a)phenylketonuria
b)alkaptonuria
c)Hartnups disease
d)Homocystinuria
Source : http://www.kmcmedicos.com
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