Syllabus of Jamia Hamdard Bachelor of Pharmacy (BPharmacy) - Ist Year - BPH04 Organic Chemistry

PHARMACEUTICAL CHEMISTRY I
ORGANIC CHEMISTRY (THEORY)
Total Teaching Hours: 50

1. Basic Principles and Concepts of Organic Chemistry

Polarity of bonds and molecules, dipole moment, resonance, inductive and electromeric effects, intramolecular intermolecular hydrogen bonding, acids and bases.

2. Stereochemistry

Stereoisomerism, optical activity, enantiomers, Diasteriomerism, mesostructures, specification of R and S, D and L configuration, racemic modification and resolution of recemic mixtures, conformational analysis, geometrical isomerism, it’s nature of formation, nomenclature of isomers and determination of configuration. Structure, nomenclature, preparation and reactions/properties of the following groups of compounds (including mechanism of reactions wherever necessary).

3. Aliphatic & Alicyclic Hydrocarbons

Alkanes, alkenes, alkynes, cycloalkanes, Bayer strain theory

4. Alkyl Halides

SN1 and SN2 reaction mechanism and stereochemistry, Dehydrohalogenation of alkyl halides, E1 and E2 mechanism, chloroform, carbon tetrachloride, trichloroethylene and halothane.

5. Aliphatic Alcohols

(i) Primary, secondary and tertiary alcohol, methanol, ethanol, proof spirit, denatured alcohol, methylated spirit.

(ii) Di and trihydric alcohols: glycols, glycerol, ethylene glycol, propylene glycol and dimercaprol.

6. Ethers

Thioethers, divinyl ether, solvent ether, anaesthetic ether.

7. Aldehydes and Ketones

Formaldehyde, acetaldehyde and their polymers, mechanism of aldol condensation, Classen condensation, Cannizzaro’s reaction, Benzoin condensation, Perkin’s condensation, Witting reaction, Mannich reaction.

8. Saturated Monocarboxylic Acids

Formic acid, acetic acid and their derivatives, propionic acid, butyric acid, valeric acid, palmitic acid And stearic acid, ethyl nitrate, acylhalides, lactic acid, lactides, lactones and gluconic acid.

9. Di and Tricarboxylic Acids

Oxalic acid, malonic acid, succinic acid and their amide and imide derivatives, maleic acid and fumaric acid, malic acid, glutaric acid, tartaric acid, citric acid and adipic acid.

10. Aliphatic amines and related compounds

Alkylamines, ß- hydroxy and ß-alkylamines, diamines, urea and ureides, Hofmann’s rearrangement, differentiation of 1°, 2° and 3° amines, dextropropoxyphene hydrochloride, cramiphen hydrochloride, dicyclamine hydrochloride, mustine hydrochloride, cyclamic acid, thiambutosine.

11. Organometallic compounds

Grignard’s reagent their preparation and synthetic applications.

12. Carbanions

Reactions involving carbanions, malonic ester, synthesis of carboxylic acids, acetoacetic ester, synthesis of ketones, decarboxylation of ß-ketoacids and malonic acids, direct and indirect alkylation of esters And ketones, alkylation of carbonyl compounds via enamines, a, ß-unsaturated carbonyl compounds (conjugate addition) including Michael and Diels - Alder reaction.

PRACTICAL
Total Hours: 100

1. Lassaigne's test for nitrogen, sulphur and halogens.
2. Identification of organic compounds based on solubility and functional group test.
3. Performance of qualitative test for alkaloids, carbohydrates, glycosides, proteins and amino acids.
4. Test for identity of selected drugs: atropine, caffeine, quinine, glucose, sucrose, ascorbic acid, aspirin And paracetamol.

Books Recommended:
1. R.T. Morison and R.N. Boyd: Organic Chemistry, Allyn and Bacon lnc, Boston, USA.
2. I.L. Finar: Organic Chemis try, Vol.1, Ale English Language Book Society and Longman Group Limited, London.
3. J.B. Hendrickson, D.J. Cram and C.S. Hammond: Organic Chemistry, McGraw Hill, Kogakusha, Limited, Tokyo.
4. P. Sykes: A Guide books to mechanism in Organic Chemistry, Orient Longman, New Delhi.
5. L.M. Atherden: Bentley and Drivers - Textbook of Pharmaceutical Chemistry, Oxford University Press, Delhi.
6. A.A. Siddiqui & Mohd. Ali: Practical Pharmaceutical Chemistry, New Delhi.
7. S.N. Pandeya: A textbook of pharmaceutical organic chemistry (Mechanistic approach) Vol- I, S.G.Publishers, Varanasi.

Get Latest Job, Admission & Exam Alerts in your E-mail.
Enter Your Email Address :